Miranda M. Lim, M.D., Ph.D., a neurology resident and post-doctoral researcher in Holtzman’s lab, performed long-term behavioral experiments with the mice. She discovered that three weeks of chronic rest deprivation accelerated amyloid plaque deposition in the mind. In contrast, when mice received almorexant for just two months, plaque deposition significantly decreased, dropping by a lot more than 80 % in a few brain areas. ‘This suggests the chance that a treatment such as this could be tested to find if it could delay the onset of Alzheimer’s disease,’ says Holtzman. Holtzman notes that not only does the chance of Alzheimer’s boost with age, the sleep/wake cycle also begins to break down, with older adults getting much less and much less sleep progressively.With the increasing option of rich patient data, we can better anticipate how the patients we manage will take their medications, stated Niteesh Choudhry, MD, PhD, associate doctor, Division of Pharmacoeconomics and Pharmacoepidemiology, Brigham and Women's Hospital and associate professor, Harvard Medical College and the study’s senior author. This extensive research implies that by concentrating on a patient’s initial, short-term medication filling behavior – are they or are they not refilling their prescription promptly during the first few months of therapy – we are able to predict with great accuracy whether a patient will continue to take the medication as prescribed over the long-term.

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